HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.

  title={HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.},
  author={Bo Qiu and Daniel J Ackerman and Danielle J. Sanchez and Bo Li and Joshua D. Ochocki and Alison Grazioli and Ekaterina Bobrovnikova-Marjon and J Alan Diehl and Brian Keith and M Celeste Simon},
  journal={Cancer discovery},
  volume={5 6},
UNLABELLED Two hallmarks of clear-cell renal cell carcinoma (ccRCC) are constitutive hypoxia-inducible factor (HIF) signaling and abundant intracellular lipid droplets (LD). However, regulation of lipid storage and its role in ccRCC are incompletely understood. Transcriptional profiling of primary ccRCC samples revealed that expression of the LD coat protein gene PLIN2 was elevated in tumors and correlated with HIF2α, but not HIF1α, activation. HIF2α-dependent PLIN2 expression promoted lipid… CONTINUE READING
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