HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.

@article{Du2008HIF1alphaIT,
  title={HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.},
  author={Rose Du and Kan V. Lu and Claudia Petritsch and Patty Liu and Ruth Ganss and Emmanuelle Passegu{\'e} and Hanqiu Song and Scott VandenBerg and Randall S Johnson and Zena Werb and Gabriele Bergers},
  journal={Cancer cell},
  year={2008},
  volume={13 3},
  pages={
          206-20
        }
}
Development of hypoxic regions is an indicator of poor prognosis in many tumors. Here, we demonstrate that HIF1alpha, the direct effector of hypoxia, partly through increases in SDF1alpha, induces recruitment of bone marrow-derived CD45+ myeloid cells containing Tie2+, VEGFR1+, CD11b+, and F4/80+ subpopulations, as well as endothelial and pericyte progenitor cells to promote neovascularization in glioblastoma. MMP-9 activity of bone marrow-derived CD45+ cells is essential and sufficient to… CONTINUE READING
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