HIF1α is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development.

@article{Bentovim2012HIF1IA,
  title={HIF1α is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development.},
  author={Lital Bentovim and Roy Amarilio and Elazar Zelzer},
  journal={Development},
  year={2012},
  volume={139 23},
  pages={4473-83}
}
Collagen production is fundamental for the ontogeny and the phylogeny of all multicellular organisms. It depends on hydroxylation of proline residues, a reaction that uses molecular oxygen as a substrate. This dependency is expected to limit collagen production to oxygenated cells. However, during embryogenesis, cells in different tissues that develop under low oxygen levels must produce this essential protein. In this study, using the growth plate of developing bones as a model system, we… CONTINUE READING
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