HIF1α and metabolic reprogramming in inflammation.

  title={HIF1α and metabolic reprogramming in inflammation.},
  author={Sarah E. Corcoran and Luke A J O'Neill},
  journal={The Journal of clinical investigation},
  volume={126 10},
HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the induction of proinflammatory genes, notably Il1b. The mechanism of LPS-stimulated HIF1α induction involves succinate, which inhibits prolyl… CONTINUE READING
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