HIF stabilizing agents: shotgun or scalpel?

  title={HIF stabilizing agents: shotgun or scalpel?},
  author={Tiina M. Asikainen and Carl W. White},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={293 3},
THE FETUS DEVELOPS IN HYPOXIA (3–5% O2), which is essential for the vasculature. Vascular growth, in turn, is required for lung development (11). For these processes, the essential role of the transcription factor hypoxia-inducible factor (HIF) is increasingly apparent. Genetic inactivation of either HIF-1 or -2 in mice leads to fetal or neonatal lethality because of major developmental defects including those involving the vasculature. Preterm delivery occurs in 12% of births and causes 85% of… CONTINUE READING