HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably.

@article{Kopp2011HIFSA,
  title={HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably.},
  author={Renate Kopp and Louise K{\"o}blitz and M. Egg and Bernd Pelster},
  journal={Physiological genomics},
  year={2011},
  volume={43 9},
  pages={506-16}
}
Exercise as well as hypoxia cause an increase in angiogenesis, changes in mitochondrial density and alterations in metabolism, but it is still under debate whether the hypoxia inducible factor (HIF) is active during both situations. In this study gene expression analysis of zebrafish larvae that were raised under normoxic, hypoxic, or training conditions were compared, using microarray analysis, quantitative real-time PCR and protein data. Although HIF expression is posttranslationally… CONTINUE READING
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