HIF-regulated HO-1 gene transfer improves the post-ischemic limb recovery and diminishes TLR-triggered immune responses - Effects modified by concomitant VEGF overexpression.

@article{Jawa2015HIFregulatedHG,
  title={HIF-regulated HO-1 gene transfer improves the post-ischemic limb recovery and diminishes TLR-triggered immune responses - Effects modified by concomitant VEGF overexpression.},
  author={Agnieszka Jaźwa and Mateusz Stoszko and Mateusz Michał Tomczyk and Karolina Bukowska-Strakov{\'a} and Chantal Pichon and Alicja Jozkowicz and Jozef Dulak},
  journal={Vascular pharmacology},
  year={2015},
  volume={71},
  pages={127-38}
}
Heme oxygenase-1 (HO-1) mitigates cellular injury by antioxidant, anti-apoptotic, anti-inflammatory and proangiogenic effects. Vascular endothelial growth factor (VEGF) is a critical regulator of blood vessel growth. Their coordinated action was analyzed in a model of femoral artery ligation (FAL) in mice lacking HO-1 gene (HO-1 KO). Gastrocnemius skeletal muscles of HO-1 KO mice were preemptively injected with plasmids containing hypoxia-response element (HRE) driving the expression of only HO… CONTINUE READING