HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.

@article{Masson2003HIFPA,
  title={HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.},
  author={Norma Masson and Peter J Ratcliffe},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 15},
  pages={
          3041-9
        }
}
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that plays a crucial role in mediating cellular responses to oxygen. Oxygen availability influences multiple steps in HIF activation and recent studies have indicated that at least two steps in this process are governed by a novel mode of signal transduction involving enzymatic hydroxylation of specific amino acid residues in HIF-alpha subunits by a series of 2-oxoglutarate (2-OG)-dependent oxygenases. These enzymes are non… CONTINUE READING

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