HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition

@article{Ekman2014HIFmediatedMS,
  title={HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition},
  author={Mari Ekman and Bengt Uvelius and Sebastian Albinsson and Karl Sw{\"a}rd},
  journal={Laboratory Investigation},
  year={2014},
  volume={94},
  pages={557-568}
}
Prior work demonstrated increased levels of hypoxia-inducible factor-1α (HIF-1α) in the bladder following outlet obstruction, associated with bladder growth and fibrosis. Here we hypothesized that HIF induction in outlet obstruction also switches energetic support of contraction from mitochondrial respiration to glycolysis. To address this hypothesis, we created infravesical outlet obstruction in female Sprague–Dawley rats and examined HIF induction and transcriptional activation. HIF-1… CONTINUE READING