HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction.

@article{LabrousseArias2016HIF2mediatedIO,
  title={HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction.},
  author={David Labrousse-Arias and Raquel Castillo-Gonz{\'a}lez and Natasha M. Rogers and Mar Torres-Capelli and Bianca Barreira and Juli{\'a}n Aragon{\'e}s and Angel Cogolludo and Jeffrey S. Isenberg and Mar{\'i}a J Calzada},
  journal={Cardiovascular research},
  year={2016},
  volume={109 1},
  pages={
          115-30
        }
}
AIMS Hypoxic conditions stimulate pulmonary vasoconstriction and vascular remodelling, both pathognomonic changes in pulmonary arterial hypertension (PAH). The secreted protein thrombospondin-1 (TSP1) is involved in the maintenance of lung homeostasis. New work identified a role for TSP1 in promoting PAH. Nonetheless, it is largely unknown how hypoxia regulates TSP1 in the lung and whether this contributes to pathological events during PAH. METHODS AND RESULTS In cell and animal experiments… CONTINUE READING

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