HIF-1alpha mediates the induction of IL-8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT-like behaviour.

@article{Cane2010HIF1alphaMT,
  title={HIF-1alpha mediates the induction of IL-8 and VEGF expression on infection with Afa/Dr diffusely adhering E. coli and promotes EMT-like behaviour.},
  author={Ga{\"e}lle Cane and Amandine Ginouv{\`e}s and Sandrine Marchetti and R. Valls Busca and Jacques Pouyssegur and Edurne Berra and P. B. Hofman and Val{\'e}rie Vouret-Craviari},
  journal={Cellular microbiology},
  year={2010},
  volume={12 5},
  pages={
          640-53
        }
}
Microbes regulate a large panel of intracellular signalling events that can promote inflammation and/or enhance tumour progression. Indeed, it has been shown that infection of human intestinal cells with the Afa/Dr diffusely adhering E. coli C1845 strain induces expression of pro-angiogenic and pro-inflammatory genes. Here, we demonstrate that exposure of cryptic-like intestinal epithelial cells to C1845 bacteria induces HIF-1alpha protein levels. This effect depends on the binding of F1845… CONTINUE READING
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