HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes.

@article{Pfander2003HIF1alphaCE,
  title={HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes.},
  author={David Pfander and Thorsten Cramer and Ernestina Schipani and Randall S Johnson},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 9},
  pages={
          1819-26
        }
}
The transcription factor HIF-1alpha plays a crucial role in modifying gene expression during low oxygen tension. In a previous study, we demonstrated that HIF-1alpha is essential for chondrocyte growth arrest and survival in vivo. To explore further the role of HIF-1alpha in cartilage biology, we undertook studies with primary epiphyseal chondrocytes with a targeted deletion of HIF-1alpha. In this study, we show that HIF-1alpha is necessary for regulating glycolysis under aerobic and anaerobic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 63 CITATIONS, ESTIMATED 65% COVERAGE

Hif-1α regulates differentiation of limb bud mesenchyme and joint development

  • The Journal of cell biology
  • 2007
VIEW 8 EXCERPTS
CITES BACKGROUND & METHODS

Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair.

  • Current topics in developmental biology
  • 2004
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2004
2019

CITATION STATISTICS

  • 1 Highly Influenced Citations