HIF-1 mediates the Warburg effect in clear cell renal carcinoma.

  title={HIF-1 mediates the Warburg effect in clear cell renal carcinoma.},
  author={Gregg L Semenza},
  journal={Journal of bioenergetics and biomembranes},
  volume={39 3},
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. O(2)-dependent hydroxylation of two proline residues in the HIF-1alpha subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1alpha, leading to its degradation by the proteasome. In the majority of cases of the clear cell type of renal carcinoma, both VHL… CONTINUE READING


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