HIF-1 and mechanisms of hypoxia sensing.

  title={HIF-1 and mechanisms of hypoxia sensing.},
  author={Gregg L Semenza},
  journal={Current opinion in cell biology},
  volume={13 2},
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein. Interaction of HIF-1 alpha transactivation domains with coactivators is induced by hypoxia. The signal transduction pathway remains enigmatic, but involves generation of… CONTINUE READING
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