HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation.

@article{Ockaili2005HIF1AA,
  title={HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation.},
  author={Ramzi A Ockaili and Ramesh Natarajan and Fadi N. Salloum and Bernard J Fisher and Drew G. Jones and Alpha A Berry Fowler and Rakesh C. Kukreja},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 2},
  pages={
          H542-8
        }
}
The CXC chemokine IL-8, which promotes adhesion, activation, and transmigration of polymorphonuclear neutrophils (PMN), has been associated with production of tissue injury in reperfused myocardium. Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric peptide that is a key regulator of genes such as heme oxygenase (HO)-1 expressed under hypoxic conditions. We hypothesized that HO-1 plays an important role in regulating proinflammatory mediator production under conditions of ischemia… 

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