HIF-1-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia

@inproceedings{Sheldon2009HIF1DeficientMH,
  title={HIF-1-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia},
  author={R. Ann Sheldon and Damjan Osredkar and Christina K L Lee and Xiangning Jiang and Dezhi Mu and D M Ferriero},
  year={2009}
}
Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1 (HIF-1 ) may promote cell survival in hypoxic or ischemic brain. To help understand the role of HIF-1 in neonatal hypoxic-ischemic brain injury, mice with conditional neuron-specific inactivation of HIF-1 underwent hypoxia-ischemia (HI). Mice heterozygous for Cre… CONTINUE READING