HIF-1–dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia

  title={HIF-1–dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia},
  author={Holger K. Eltzschig and Parween Abdulla and Edgar Hoffman and Kathryn E. Hamilton and Dionne Daniels and Caroline Schoenfeld and Michaela L{\"o}ffler and German Reyes and Michael Duszenko and Jorn Karhausen and Andreas Robinson and Karen A. Westerman and Imogen R. Coe and Sean P Colgan},
  journal={The Journal of Experimental Medicine},
  pages={1493 - 1505}
Extracellular adenosine (Ado) has been implicated as central signaling molecule during conditions of limited oxygen availability (hypoxia), regulating physiologic outcomes as diverse as vascular leak, leukocyte activation, and accumulation. Presently, the molecular mechanisms that elevate extracellular Ado during hypoxia are unclear. In the present study, we pursued the hypothesis that diminished uptake of Ado effectively enhances extracellular Ado signaling. Initial studies indicated that the… CONTINUE READING


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Adenosine A 2 A receptor stimulation increases angiogenesis by down - regulating production of the antiangiogenic matrix protein thrombospondin 1

  • H. K. Eltzschig, J. C. Ibla, +5 authors S. P. Colgan
  • Mol . Pharmacol .
  • 2005

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