HIF-1α up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells

@article{Wang2012HIF1UN,
  title={HIF-1α up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells},
  author={Qiang Wang and Li-hong Li and Guodong Gao and Gang Sam Wang and Liang Qu and Jin-ge Li and Chunmei Wang},
  journal={Molecular Biology Reports},
  year={2012},
  volume={40},
  pages={3723-3729}
}
Hypoxia-inducible signaling pathway is involved in many pathological processes, such as adaptiveness regulation of plateau environment, myocardial ischemia and tumorigenesis. NDRG1 is a member of the N-myc downregulated gene (NDRG) family, and it has strong hypoxia stress reaction functions. Although the cellular responses to hypoxia are well known, little is known about the interaction between hypoxia-inducible transcription factor (HIF)-1α and NDRG1. In this study, we cloned HIF-1α CDS, NDRG1… CONTINUE READING