HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells.

@article{Tang2014HIF1IV,
  title={HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells.},
  author={Na-na Tang and Hong Zhu and Hong-jie Zhang and Wei-Feng Zhang and Hai-lin Jin and Lu Wang and Pin Wang and Gui-Jun He and B B Hao and Ruihua Shi},
  journal={World journal of gastroenterology},
  year={2014},
  volume={20 47},
  pages={17894-904}
}
AIM To investigate whether hypoxia inducible factor (HIF)-1α modulates vasculogenic mimicry (VM) by upregulating VE-cadherin expression in esophageal squamous cell carcinoma (ESCC). METHODS Esophageal squamous cancer cell lines Eca109 and TE13 were transfected with plasmids harboring small interfering RNAs targeting HIF-1α or VE-cadherin. The proliferation and invasion of esophageal carcinoma cells were detected by MTT and Transwell migration assays. The formation of tubular networks of cells… CONTINUE READING
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