HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation

@article{He2013HIF1DM,
  title={HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation},
  author={M He and Q Wang and Q-Q Yin and Jiazhen Tang and Y Lu and C Zhou and C Duan and D-L Hong and Takashi Tanaka and G Chen and Qiannan Zhao},
  journal={Cell Death and Differentiation},
  year={2013},
  volume={20},
  pages={408-418}
}
Hypoxia-inducible factor 1 (HIF-1) is a crucial transcription factor for the cellular adaptive response to hypoxia, which contributes to multiple events in cancer biology. MicroRNAs (miRNAs) are involved in almost all cellular activities such as differentiation, proliferation, and apoptosis. In this work, we use miRNA microarrays to profile miRNA expression in acute myeloid leukemia (AML) cells with inducible HIF-1α expression, and identify 19 differentially expressed miRNAs. Our study shows… CONTINUE READING

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In this work , we use miRNA microarrays to profile miRNA expression in acute myeloid leukemia ( AML ) cells with inducible HIF-1α expression , and identify 19 differentially expressed miRNAs .
In this work , we use miRNA microarrays to profile miRNA expression in acute myeloid leukemia ( AML ) cells with inducible HIF-1α expression , and identify 19 differentially expressed miRNAs .
In this work , we use miRNA microarrays to profile miRNA expression in acute myeloid leukemia ( AML ) cells with inducible HIF-1α expression , and identify 19 differentially expressed miRNAs .
In this work , we use miRNA microarrays to profile miRNA expression in acute myeloid leukemia ( AML ) cells with inducible HIF-1α expression , and identify 19 differentially expressed miRNAs .
In this work , we use miRNA microarrays to profile miRNA expression in acute myeloid leukemia ( AML ) cells with inducible HIF-1α expression , and identify 19 differentially expressed miRNAs .
TRANSCRIPTION FACTORIs biochemical function of gene productHypoxia-Inducible Factor 1
Hypoxia - inducible factor 1 ( HIF-1 ) is a crucial transcription factor for the cellular adaptive response to hypoxia , which contributes to multiple events in cancer biology .
Hypoxia - inducible factor 1 ( HIF-1 ) is a crucial transcription factor for the cellular adaptive response to hypoxia , which contributes to multiple events in cancer biology .
Hypoxia - inducible factor 1 ( HIF-1 ) is a crucial transcription factor for the cellular adaptive response to hypoxia , which contributes to multiple events in cancer biology .
STAT proteinIs chemical classification of gene productStat3 protein
More intriguingly , miR-17 and miR-20a directly inhibit the p21 and STAT3 ( signal transducer and activator of transcription 3 ) expression , both of which can reverse miR-17/miR-20a - mediated abrogation of HIF-1α-induced differentiation .
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