HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia.

@article{Liu2010HIF1dependentAP,
  title={HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia.},
  author={X Liu and Yi Juan Su and Hong Zhu and Ji Rong Cao and Wan-jing Ding and Yuchen Zhao and Qiao-jun He and Bo Yang},
  journal={Pharmacological research},
  year={2010},
  volume={62 5},
  pages={416-25}
}
Novel therapeutic strategies are needed to address and to solve the emerging problem of hypoxia-induced resistance to anticancer drugs. N-(4-Hydroxyphenyl)retinamide (4-HPR) exhibits potent anticancer and chemopreventive activities, but its inefficiency under hypoxia, through undetermined mechanisms, may contribute to its lack of activity in clinical trials. In this study, we showed that under normoxia, 4-HPR resulted in apoptosis and ultimate cell death; in contrast, under hypoxia, autophagy… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Roles of hypoxia - inducible factor - 1 alpha ( HIF - 1 alpha ) versusHIF - 2 alpha in the survival of hepatocellular tumor spheroids

H Menrad, C Werno, +3 authors N Dehne
Hepatology • 2010

Argi - nine deiminase as a novel therapy for prostate cancer induces autophagy and caspase - independent apoptosis

J Cao, D Xu, +3 authors H Zhu
Cancer Res • 2009

Similar Papers

Loading similar papers…