HIF-1α and VEGF Expression after Transient Global Cerebral Ischemia

@inproceedings{Pichiule2003HIF1AV,
  title={HIF-1α and VEGF Expression after Transient Global Cerebral Ischemia},
  author={Paolo Pichiule and Faton Agani and Juan Carlos Mendez Chavez and Kui Xu and Joseph C. LaManna},
  year={2003}
}
Hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression were studied in rat cerebral cortex after reversible global cerebral ischemia produced by cardiac arrest and resuscitation. Immunoblot analysis showed a significant induction of HIF-1α protein after 1 hour of recovery from cardiac arrest which remained elevated for at least 12 hours. Upregulation of VEGF mRNA and protein were also observed but this was delayed in comparison to the HIF- 1α response… CONTINUE READING

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