HIF-1α Inhibits Wnt Signaling Pathway by Activating Sost Expression in Osteoblasts

@inproceedings{Chen2013HIF1IW,
  title={HIF-1α Inhibits Wnt Signaling Pathway by Activating Sost Expression in Osteoblasts},
  author={Dafu Chen and Yang Li and Zhiyu Zhou and Chengai Wu and Yonggang Xing and Xuenong Zou and Wei Tian and Chi Zhang},
  booktitle={PloS one},
  year={2013}
}
The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains poorly understood. One of the driving forces is hypoxia. As a master regulator of hypoxia, hypoxia-inducible factor-1α (HIF-1α) has been reported to couple angiogenesis to osteogenesis. Our recent study has demonstrated that osteoblast growth is inhibited under hypoxia and that HIF-1α cooperates with Osterix (Osx) to inhibit Wnt pathway… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 35 references

Wnt signaling: a win for bone.

Archives of biochemistry and biophysics • 2008
View 4 Excerpts
Highly Influenced

Molecular mechanisms of osteoblast-specific transcription factor Osterix effect on bone formation

C Zhang
Beijing Da Xue Xue Bao • 2012
View 1 Excerpt

Role of HIF-1alpha in skeletal development.

Annals of the New York Academy of Sciences • 2010
View 1 Excerpt

Transcriptional regulation of bone formation by the osteoblastspecific transcription factor Osx

C Zhang
J Orthop Surg Res • 2010
View 1 Excerpt

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