HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus

@article{Semenza2001HIF1OA,
  title={HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus},
  author={Gregg L Semenza},
  journal={Cell},
  year={2001},
  volume={107},
  pages={1-3}
}
Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation. 
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References

Publications referenced by this paper.
Showing 1-7 of 7 references

Faseb J

M. Gassmann
15, 1312–1314. • 2001

Science dence suggests that the three mammalian PHDs may 292, 464–468. have differing hydroxylase activities toward Pro-564

M. Ivan, K. Kondo, +4 authors Salic
2001
View 2 Excerpts

Genes Dev

G. L. Semenza
14, 1983–1991. • 2000

J

R. H. Wenger
Exp. Biol. 203, 1253–1263. • 2000

Microbiol

B. L. Taylor, I. B. Zhulin
Mol. Biol. Rev. 63, • 1999
View 1 Excerpt

Respir

R. O. Poyton
Physiol. 115, 119–133. • 1999

The extent to which the three mammalian

L. E. Huang, J. Gu, M. Schau, H. F. Bunn
1998

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