HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus

  title={HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus},
  author={Gregg L Semenza},
Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation. 
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