HID-1 is required for homotypic fusion of immature secretory granules during maturation

  title={HID-1 is required for homotypic fusion of immature secretory granules during maturation},
  author={Wen Du and Maoge Zhou and Wei Zhao and Dongwan Cheng and Lifen Wang and Jingze Lu and Eli Song and Wei Feng and Yanhong Xue and Pingyong Xu and Tao Xu},
Secretory granules, also known as dense core vesicles, are generated at the trans-Golgi network and undergo several maturation steps, including homotypic fusion of immature secretory granules (ISGs) and processing of prehormones to yield active peptides. The molecular mechanisms governing secretory granule maturation are largely unknown. Here, we investigate a highly conserved protein named HID-1 in a mouse model. A conditional knockout of HID-1 in pancreatic β cells leads to glucose… CONTINUE READING


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