HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans-Golgi network acidification

@inproceedings{Hummer2017HID1CF,
  title={HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans-Golgi network acidification},
  author={Blake H. Hummer and Noah F. de Leeuw and Christian Burns and Lan Chen and Matthew S. Joens and Bethany Hosford and James A. J. Fitzpatrick and C{\'e}dric S Asensio},
  booktitle={Molecular biology of the cell},
  year={2017}
}
Large dense core vesicles (LDCVs) mediate the regulated release of neuropeptides and peptide hormones. They form at the trans-Golgi network (TGN), where their soluble content aggregates to form a dense core, but the mechanisms controlling biogenesis are still not completely understood. Recent studies have implicated the peripheral membrane protein HID-1 in neuropeptide sorting and insulin secretion. Using CRISPR/Cas9, we generated HID-1 KO rat neuroendocrine cells, and we show that the absence… CONTINUE READING
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