HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth

@inproceedings{Shibanuma2012HIC5AM,
  title={HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth},
  author={Motoko Shibanuma and Kazunori Mori and Kiyoshi Nose},
  booktitle={International journal of cell biology},
  year={2012}
}
HIC-5 is a multidomain LIM protein homologous to paxillin that serves as a molecular scaffold at focal adhesions and in the nucleus. It forms mobile molecular units with LIM-only proteins, PINCH, and CRP2 and translocates in and out of the nucleus via a nuclear export signal (NES). Of note, NES of HIC-5 is distinctive in its sensitivity to the cellular… CONTINUE READING