HGF triggers activation of the COX-2 gene in rat gastric epithelial cells: action mediated through the ERK2 signaling pathway.

@article{Jones1999HGFTA,
  title={HGF triggers activation of the COX-2 gene in rat gastric epithelial cells: action mediated through the ERK2 signaling pathway.},
  author={Michael K. Jones and Eiji Sasaki and Fabien Halter and Rama Pai and Toshikazu Nakamura and Tetsuo Arakawa and Tetsuo Kuroki and Andrzej S Tarnawski},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1999},
  volume={13 15},
  pages={
          2186-94
        }
}
Although it is established that growth factors and prostaglandins function in the maintenance of gastric mucosal integrity and in the healing of gastric mucosal injury and ulceration, the regulatory relationship between growth factors and prostaglandins in the gastric mucosa is not well characterized. Therefore, we investigated whether hepatocyte growth factor (HGF) affects expression of COX-2 (the inducible form of the prostaglandin synthesizing enzyme, cyclooxygenase) in gastric epithelial… CONTINUE READING

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