HGF suppresses the production of collagen type III and α-SMA induced by TGF-β1 in healing fibroblasts

@article{Jiang2008HGFST,
  title={HGF suppresses the production of collagen type III and α-SMA induced by TGF-β1 in healing fibroblasts},
  author={Dapeng Jiang and Zhitao Jiang and Fuyou Han and Yubo Zhang and Zhaozhu Li},
  journal={European Journal of Applied Physiology},
  year={2008},
  volume={103},
  pages={489-493}
}
The aim of this study was to examine the effectiveness of HGF in blocking TGF-β1-induced collagen III and α-smooth muscle actin (α-SMA) production in rat healing fibroblasts, fibroblasts were obtained from healing medial collateral ligament (MCL) injury. Cell culture was supplemented with 5 ng/ml of TGF-β1 along with increasing doses of HGF (10–40 ng/ml). The productions of collagen III in supernatants culture were assayed by enzyme-linked immunosorbent assay. Expression of α-SMA was assessed… CONTINUE READING