HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium.

@article{Yu2009HGFAB,
  title={HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium.},
  author={Min-A Yu and Kyung-Sook Shin and Jung Hye Kim and Yong-Il Kim and Soon Sup Chung and Sun Hee Park and Yong Lim Kim and Duk-Hee Kang},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2009},
  volume={20 3},
  pages={567-81}
}
Over time, peritoneal dialysis results in functional and structural alterations of the peritoneal membrane, but the underlying mechanisms and whether these changes are reversible are not completely understood. Here, we studied the effects of high levels of glucose, which are found in the dialysate, on human peritoneal mesothelial cells (HPMCs). We found that high concentrations of glucose induced epithelial-to-mesenchymal transition (EMT) of HPMC, suggested by decreased expression of E-cadherin… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Mesothelial toxicity of peritoneal BASIC RESEARCH www.jasn.org 580 Journal of the American Society of Nephrology

J Witowski, TO Bender, +4 authors A Jorres
J Am Soc Nephrol • 2009

thelial - to - mesenchymal transition of mesothelial cells is an early event during peritoneal dialysis and is associated with high peritoneal transport

G DelPeso, JA Jiménez-Heffernan, +10 authors R Selgas
Kidney Int Suppl • 2008

Bone morphogenic protein-7 and the kidney: current concepts and open questions.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2006

Epithelial-to-mesenchymal transition of the mesothelial cell--its role in the response of the peritoneum to dialysis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2006

Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2006

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