HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity.

@article{Trusolino2000HGFscatterFS,
  title={HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity.},
  author={Livio Trusolino and Silvia Cavassa and P Angelini and Motomo Ando and Andrea Bertotti and Paolo Maria Comoglio and Carla Boccaccio},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2000},
  volume={14 11},
  pages={1629-40}
}
Hepatocyte growth factor/scatter factor (HGF/SF) controls a genetic program known as 'invasive growth', which involves as critical steps cell adhesion, migration, and trespassing of basement membranes. We show here that in MDA-MB-231 carcinoma cells, these steps are elicited by HGF/SF but not by epidermal growth factor (EGF). Neither factor substantially alters the production or activity of extracellular matrix proteases. HGF/SF, but not EGF, selectively promotes cell adhesion on laminins 1 and… CONTINUE READING