HGF/SF in Mammary Epithelial Growth and Morphogenesis: In Vitro and In Vivo Models

@article{Kamalati2004HGFSFIM,
  title={HGF/SF in Mammary Epithelial Growth and Morphogenesis: In Vitro and In Vivo Models},
  author={Tahereh Kamalati and Birunthi Niranjan and Jeffrey Yant and Lakjaya Buluwela},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2004},
  volume={4},
  pages={69-77}
}
HGF/SF is a multifunctional cytokine whichthrough binding to its cellular receptor, c-MET, canelicit mitogenic, morphogenic and motogenic responses intarget cells. Expression of HGF/SF and c-MET has been shown to be critical in earlyembryogenesis affecting development of many organs andtissues. The effects of HGF/SF4 on established human andmouse mammary cell lines have previously been reported. This review describes the source and targetsfor HGF/SF in both human and mouse mammary tissue… Expand
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TLDR
It is demonstrated that HGF/SF and its cellular receptor, c-met, are expressed and regulated temporally during mouse mammary development and differentiation and it is found that human luminal and myoepithelial cells express c- Met differentially and that H GF/SF has different effects on these two mammary epithelial cell populations. Expand
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It is reported that overexpression of HGF/SF induces a range of alterations in the architecture of virgin mouse mammary gland, including an enhancement of ductal end bud size and numbers and hyperplastic branching morphogenesis. Expand
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In situ hybridization analysis showed that HGF/SF mRNA was restrictively expressed in the areas of future joint regions in developing limb buds and in the intercostal spaces of developing costal cartilages, suggesting that H GF/SF plays important roles in cartilage development through its multiple activities. Expand
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HEPATOCYTE growth factor/scatter factor (HGF/SF) functions as a mitogen, motogen and morphogen for a variety of cultured cells1–7. The genes for HGF/SF and its receptor (the c-met protooncogeneExpand
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