HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver.

  title={HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver.},
  author={Orit Kollet and Shoham Shivtiel and Yuan-qing Chen and Jenny Suriawinata and Swan N. Thung and Mariana D. Dabeva and Joy Kahn and Asaf Spiegel and Ayelet Dar and Sarit Samira and Polina Goichberg and Alexander Kalinkovich and Fernando Arenzana-Seisdedos and Arnon Nagler and Izhar Hardan and Michel Revel and David A. Shafritz and Tsvee Lapidot},
  journal={The Journal of clinical investigation},
  volume={112 2},
Hematopoietic stem cells rarely contribute to hepatic regeneration, however, the mechanisms governing their homing to the liver, which is a crucial first step, are poorly understood. The chemokine stromal cell-derived factor-1 (SDF-1), which attracts human and murine progenitors, is expressed by liver bile duct epithelium. Neutralization of the SDF-1 receptor CXCR4 abolished homing and engraftment of the murine liver by human CD34+ hematopoietic progenitors, while local injection of human SDF-1… CONTINUE READING
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