HFE gene knockout produces mouse model of hereditary hemochromatosis.

  title={HFE gene knockout produces mouse model of hereditary hemochromatosis.},
  author={Xiao Yan Zhou and Shunji Tomatsu and Robert E. Fleming and Seppo Parkkila and Abdul Rais Abdul Waheed and Jinxing Jiang and Y B Fei and Elizabeth M. Brunt and David A. Ruddy and C. E. Prass and Randall C. Schatzman and Rosemary O'neill and Robert S. Britton and Bruce R. Bacon and William S. Sly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 5},
Hereditary hemochromatosis (HH) is a common autosomal recessive disease characterized by increased iron absorption and progressive iron storage that results in damage to major organs in the body. Recently, a candidate gene for HH called HFE encoding a major histocompatibility complex class I-like protein was identified by positional cloning. Nearly 90% of… CONTINUE READING