HFE Genotype in Patients with Hemochromatosis and Other Liver Diseases

@article{Bacon1999HFEGI,
  title={HFE Genotype in Patients with Hemochromatosis and Other Liver Diseases},
  author={B. Bacon and J. Olynyk and E. Brunt and R. Britton and R. Wolff},
  journal={Annals of Internal Medicine},
  year={1999},
  volume={130},
  pages={953-962}
}
Hereditary hemochromatosis is a common inherited disorder of iron metabolism that affects between 1 in 200 and 1 in 400 persons of northern European descent (1). With early diagnosis and appropriate treatment, survival of patients is normal (1, 2). Recently, researchers identified a novel MHC class 1-like gene, HFE, which contains two missense mutations (3). Eighty-three percent of 178 typical patients with hemochromatosis were homozygous for one of these mutations (Cys282Tyr [C282Y]) (3… Expand
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