HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence.

@article{Hellerbrand2003HFECH,
  title={HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence.},
  author={Claus Hellerbrand and Andreas P{\"o}ppl and Arndt Hartmann and Juergen Schoelmerich and Guntram Lock},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2003},
  volume={1 4},
  pages={279-84}
}
BACKGROUND & AIMS Iron overload is observed frequently in chronic liver disease, and some studies have suggested that chronic iron overload may contribute to the pathogenesis of hepatocellular carcinoma (HCC). Heterozygosity for hereditary hemochromatosis (HH) is associated with increased body iron stores. The discovery of the HH gene HFE has enabled identification of the heterozygote status. The aim of this study was to evaluate if heterozygosity for HH is a risk factor for HCC. METHODS The… CONTINUE READING

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