HEY2 mutations in malformed hearts.

Abstract

The basic helix-loop-helix (bHLH) transcription factor Hey2 (gridlock) is an important determinant of mammalian heart development, but its role in human ventricular septal defects is unknown. Hey2 functions as a repressor through the bHLH domain. By direct sequencing, we analyzed the sequences encoding the bHLH domain of the human HEY2 in 52 explanted… (More)

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Cite this paper

@article{ReamonBuettner2006HEY2MI, title={HEY2 mutations in malformed hearts.}, author={Stella Marie Reamon-Buettner and J{\"{u}rgen Borlak}, journal={Human mutation}, year={2006}, volume={27 1}, pages={118} }