HETEs/EETs in renal glomerular and epithelial cell functions.

  title={HETEs/EETs in renal glomerular and epithelial cell functions.},
  author={Rama Natarajan and Marpadga Amarender Reddy},
  journal={Current opinion in pharmacology},
  volume={3 2},
Renal vascular effects of cyclooxygenase and cytochrome P450 metabolites of arachidonic acid have been extensively studied, with major advances having been made. More recently, studies indicate that arachidonic acid metabolites of the lipoxygenase and cytochrome P450 pathway, such as hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids, play novel roles in glomerular mesangial and epithelial cells that are relevant to the pathogenesis of kidney disease associated with diabetes and… CONTINUE READING