HETEROCYCLIZATIONS OF 3-TRIFLUOROACETYL SUBSTITUTED LACTAMS WITH CYCLIC 1,3-BIS-NUCLEOPHILES

@inproceedings{Bouillon1995HETEROCYCLIZATIONSO3,
  title={HETEROCYCLIZATIONS OF 3-TRIFLUOROACETYL SUBSTITUTED LACTAMS WITH CYCLIC 1,3-BIS-NUCLEOPHILES},
  author={Jean-Philippe Bouillon and Zbyněk Janou{\vs}ek and Heinz G{\"u}nther Viehe and Bernard Tinant and Jean Paul Declercq},
  year={1995}
}
Pyrrolidinone 2, pyrimido[1,2-a]benzimidazoles 3a-c and 1,2,4-triazolo[4,3-a]pyrimidine 4 are prepared by condensation of 3-trifluoroacetyl substituted lactams 1a–c with cyclic 1,3-bis-nucleophiles. The nature of the nucleophile determines whether the reaction occurs with or without lactam ring opening.