HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation

@article{HaapaPaananen2012HES6GI,
  title={HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation},
  author={Saija Haapa-Paananen and Santeri Kiviluoto and Marika Waltari and Marjut Puputti and John Mpindi and Pekka Kohonen and Olli Tynninen and Hannu Kalervo Haapasalo and Heikki Joensuu and Merja Per{\"a}l{\"a} and O. P. Kallioniemi},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={1299-1310}
}
Malignant glioma is the most common brain tumor with 16 000 new cases diagnosed annually in the United States. We performed a systematic large-scale transcriptomics data mining study of 9783 tissue samples from the GeneSapiens database to systematically identify genes that are most glioma-specific. We searched for genes that were highly expressed in 322 glioblastoma multiforme tissue samples and 66 anaplastic astrocytomas as compared with 425 samples from histologically normal central nervous… CONTINUE READING
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