HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression.

@article{Jacobsen2008HES1R5,
  title={HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression.},
  author={Kirsten X. Jacobsen and Jacqueline L. Vanderluit and Ruth S Slack and Paul R Albert},
  journal={Molecular and cellular neurosciences},
  year={2008},
  volume={38 3},
  pages={349-58}
}
Mammalian HES1 and HES5 are abundant in developing CNS and inhibit neurogenesis, while HES6 promotes neurogenesis. An early serotonergic differentiation marker, the 5-HT1A receptor, is repressed by HES5 and DEAF1 which recognize the C(-1019), but not G(-1019) allele of a human 5-HT1A promoter polymorphism associated with mood disorders. We tested whether HES1 and HES6 regulate transcriptional activity at this element. HES1 strongly repressed 5-HT1A transcription in neuronal and non-neuronal… CONTINUE READING

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