HERP1 is a cell type-specific primary target of Notch.

  title={HERP1 is a cell type-specific primary target of Notch.},
  author={Tatsuya Iso and Gene Chung and Yasuo Hamamori and L. Kedes},
  journal={The Journal of biological chemistry},
  volume={277 8},
Notch signaling is involved in many cell fate determination events in metazoans. Ligand binding results in proteolytic cleavage to release the signal-transducing Notch intracellular domain (NICD). The nuclear protein RBP-J kappa, when complexed with NICD, acts as a transcriptional activator which, in turn, induces a target gene of Notch such as the repressors HES/E(spl) and HERP2. Under physiological stimulation using co-culture with Notch ligand-expressing cells and target cells expressing… CONTINUE READING