HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96

  title={HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96},
  author={Jin Fa Feng and Junbo Yu and Xiaolin Pan and Zengliang Li and Z Chen and Wenjie Zhang and Bin Wang and Li Yang and Hao Xu and Guoxin Zhang and Zekuan Xu},
Pancreatic cancer is an aggressive malignancy with an extremely poor prognosis. The human ether-a-go-go-related potassium channel (HERG1) is a human rapid delayed rectifier, which is involved in many crucial cellular events. In this article, we find that HERG1 expression is dramatically increased both in pancreatic cancer tissues and cell lines, and that increased HERG1 expression is significantly related to the development of pancreatic cancer. HERG1 silencing in pancreatic cancer-derived cell… CONTINUE READING
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