HERG K+ channels: friend and foe.

@article{Vandenberg2001HERGKC,
  title={HERG K+ channels: friend and foe.},
  author={Jamie I. Vandenberg and Bruce D. Walker and Terence J. Campbell},
  journal={Trends in pharmacological sciences},
  year={2001},
  volume={22 5},
  pages={
          240-6
        }
}
The K+ channel encoded by the human ether-à-go-go related gene (HERG) is one of many ion channels that are crucial for normal action potential repolarization in cardiac myocytes. HERG encodes the pore-forming subunit of the rapid component of the delayed rectifier K+ channel, I(K(Vr)). HERG K+ channels are of considerable pharmaceutical interest as possible therapeutic targets for anti-arrhythmic agents and as the molecular target responsible for the cardiac toxicity of a wide range of… CONTINUE READING

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