HERC3 binding to and regulation by ubiquitin.

  title={HERC3 binding to and regulation by ubiquitin.},
  author={Cristina Cruz and Francesc Ventura and Ramon Bartrons and Jos{\'e} L. A. Rosa},
  journal={FEBS letters},
  volume={488 1-2},
Members of the HERC (domain homologous to E6 associated protein carboxy-terminus and RCC1 domain protein) family may function both as guanine nucleotide exchange factors and E3 ubiquitin ligases. Here we identify an unstudied member, HERC3. This protein was recognized by specific antibodies in different cell types. HERC3 was located in the cytosol and in vesicular-like structures containing beta-COP, ARF and Rab5 proteins. Involvement of HERC3 in the ubiquitin system was suggested by its… CONTINUE READING

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