HERC2 is an E3 ligase that targets BRCA1 for degradation.

@article{Wu2010HERC2IA,
  title={HERC2 is an E3 ligase that targets BRCA1 for degradation.},
  author={Wenwen Wu and Ko Sato and Ayaka Koike and Hiroyuki Nishikawa and Hirotaka Koizumi and Ashok R. Venkitaraman and Tomohiko Ohta},
  journal={Cancer research},
  year={2010},
  volume={70 15},
  pages={
          6384-92
        }
}
The breast cancer suppressor BRCA1 forms a stable heterodimeric E3 ubiquitin ligase with BARD1. Each protein controls the abundance and stability of the other, and loss of the interaction leads to BRCA1 degradation. Here, we show that HERC2, a protein recently implicated in DNA damage repair, targets BARD1-uncoupled BRCA1 for degradation. HERC2 shuttles between the nucleus and the cytoplasm. Its COOH-terminal HECT-containing domain interacts with an NH(2)-terminal degron domain in BRCA1. HERC2… CONTINUE READING

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