HERC2-USP20 axis regulates DNA damage checkpoint through Claspin

Abstract

The DNA damage response triggers cell-cycle checkpoints, DNA repair and apoptosis using multiple post-translational modifications as molecular switches. However, how ubiquitination regulates ATR signaling in response to replication stress and single-strand break is still unclear. Here, we identified the deubiquitination enzyme (DUB) USP20 as a pivotal… (More)
DOI: 10.1093/nar/gku1034

6 Figures and Tables

Topics

  • Presentations referencing similar topics