HER2 testing: a review of detection methodologies and their clinical performance

  title={HER2 testing: a review of detection methodologies and their clinical performance},
  author={J. Laudadio and D. Quigley and R. Tubbs and D. Wolff},
  journal={Expert Review of Molecular Diagnostics},
  pages={53 - 64}
  • J. Laudadio, D. Quigley, +1 author D. Wolff
  • Published 2007
  • Biology, Medicine
  • Expert Review of Molecular Diagnostics
  • The ERBB2 proto-oncogene, commonly referred to as the human epidermal growth factor receptor-2 (HER2) gene, encodes a 185 kd receptor tyrosine kinase. Overexpression of the protein leads to constitutive activity of the HER2 receptor and breast tumor development through enhanced cell proliferation, survival, motility and adhesion. Overabundance of the HER2 receptor, typically caused by amplification of the HER2 gene, is present in approximately 10–30% of invasive breast cancers, and is… CONTINUE READING
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