HER2 status in early breast cancer: relevance of cell staining patterns, gene amplification and polysomy 17.

@article{Torrisi2007HER2SI,
  title={HER2 status in early breast cancer: relevance of cell staining patterns, gene amplification and polysomy 17.},
  author={R. L. Torrisi and Nicole Rotmensz and Vincenzo Bagnardi and Giuseppe Viale and Barbara J Del Curto and Patrizia Dell'orto and Paolo Alberto Veronesi and Alberto Luini and Claudia D'Alessandro and Anna Cardillo and Aron Goldhirsch and Marco Colleoni},
  journal={European journal of cancer},
  year={2007},
  volume={43 16},
  pages={2339-44}
}
The prevalence of HER2 amplification according to the percentage of positively stained cells, of polysomy 17 and their correlation with clinical and pathologic characteristics were retrospectively evaluated in a population of 415 breast cancers where fluorescence in situ hybridisation (FISH) was performed to clarify HER2 status previously determined by immunohistochemistry. Forty-two tumours with intense and complete staining in >50% of cells were selected from the same database as internal… CONTINUE READING

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