HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor.

Abstract

HER2 receptor, for its involvement in tumorigenesis, has been largely studied as topic in cancer research. In particular, the employment of trastuzumab (Herceptin), a humanized anti-HER2 antibody, showed several clinical benefits in the therapy against the breast cancer. Moreover, for its accessible extracellular domain, this receptor is considered an ideal… (More)

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Cite this paper

@article{Calce2015HER2mediatedAD, title={HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor.}, author={Enrica Calce and Luca Monfregola and Michele Saviano and Stefania De Luca}, journal={Current medicinal chemistry}, year={2015}, volume={22 21}, pages={2525-38} }